Possible Clues:

• The trouble is one is so hearty about the saints
• Worry, despite keeping twin sons in healthy housing
• Heated argument
• More than an inconvenience
• Harass, has half of sleigh remaining
• Beset
• Fuss about ambassador protecting girl, first to last
• Pain in the behind
• Having to pull round ship is a nuisance
• Trouble gets Les confused