Possible Clues:

• Film in which Joe Pesci does not curse
• Film in which Marv says, "He's only a kid, Harry. We can take him."
• 1990 film that Roger Ebert called 'so implausible that it makes it hard for us to really care about the plight of the kid'
• 1990 film starring Macaulay Culkin
• Film in which Joe Pesci plays a criminal
• Huge holiday film
• Classic film with a screaming boy on its poster
• Hit movie with the tagline 'A family comedy without the family'
• A large individual going under in film
• Highest-grossing Christmas movie at the U.S. box office