Possible Clues:

• Frantic detectives directed across river
• At one's wits' end with hash - drugs that circulate island
• Getting into beer, one good person raving
• Sit awkwardly in breeze, becoming upset
• At one's wits' end with hash drugs that circulate island
• Deeply agitated
• One on street beset by drink, driven mad
• Deeply agitated, first to get wrapped up in breeze
• Detectives given instruction to arrest Republican in a state
• Daughter is instructed about Rex, being very worried