Possible Clues:

• First couple in Arizona initially leaving another part of US for a third
• The 'K' of 'KCMO'
• Toto's home state
• Tallgrass Prairie National Preserve setting
• Home of the continental U.S.'s geographic center
• Home to Dorothy and Toto
• 'Toto, I've a feeling we're not in ... anymore' (The Wizard of Oz)
• US state, not a Republican state
• Its highest point is Mount Sunflower
• The 'home' in 'There's no place like home'