| Iowa college town |
AMES |
| Item smashed before a ship's maiden voyage |
CHAMPAGNEBOTTLE |
| Itty-bitty |
TEENSY |
| Jewelry fastener |
CLASP |
| John Philip ___, 'The March King' |
SOUSA |
| Kitchen brand that could be a losing tic-tac-toe line |
OXO |
| Klutz's cry |
OOPS |
| Lauder of cosmetics |
ESTEE |
| Leonardo DiCaprio role in a 1996 Shakespeare adaptation |
ROMEO |
| Long-handled garden tool |
HOE |
| Looked sleazily |
LEERED |
| Major blood vessel |
AORTA |
| Many a pet shelter pet, at one point |
STRAY |
| Meg who played each of the three female leads in 'Joe Versus the Volcano' |
RYAN |
| Nobles above viscounts |
EARLS |
| Old Testament book between Daniel and Joel |
HOSEA |
| Once-sacred slitherers |
ASPS |
| One of many for a Swiss Army knife |
USE |
| One-act Oscar Wilde tragedy |
SALOME |
| Palindromic preposition in poems |
ERE |
| Perfect places |
EDENS |
| Pig's pad |
STY |
| Pilot and Civic manufacturer |
HONDA |
| Praise to the skies |
EXALT |
| Prefix with natal |
NEO |
| Ready to respond, as a doctor |
ONCALL |
| Regarding |
ASTO |
| Second-largest world religion |
ISLAM |
| See 7-Down |
READER |
| Shindig |
BASH |
| Slangy question of greeting ... or a hint to 18-, 23-, 40- and 53-Across |
WHATSPOPPIN |
| Speak hoarsely |
RASP |
| Speed ___ (fast driver) |
DEMON |
| Taj Mahal locale |
AGRA |
| Windshield clearer |
WIPER |
| With 25-Across, digital magazine with the slogan 'Cure ignorance' |
UTNE |
| Word before rest or wrestle |
ARM |
| Yammerer's sentence type |
RUNON |
| ___ or nothing |
ALL |