Related Clues:

• Piss off
• Raise one's hackles
• Try the patience of
• Get on the bad side of
• Be a thorn in the side of
• Bother greatly
• Bug the hell out of
• Be a nuisance to
• Be a pain to
• Do some button-pushing, so to speak
• Be a pest
• Test the patience of
• Bug like a 24-Down
• Get on the nerves of
• Rattle one's cage