Related Clues:

• Trouble big-time
• Honk off
• Rub up the wrong way with loud music to go off
• Patronize, as a bistro
• Make really mad
• Ruffle the feathers of
• Bug, and then some
• Irritate considerably
• Irritate big-time
• Anger (with "up")
• Incite anger
• Ladder, part 6
• Make agitated
• Really anger
• Cause a stir