Related Clues:

• Hose woe
• Major screw-up
• Knot that's easily loosened
• Sock mishap
• Monkey wrench
• More than just a mistake
• Sweater woe
• Total mess
• It often leads to a run
• Plan impediment
• Trip up
• Fishing-line problem
• Scratch on a gem, e.g.
• Design ___
• Hidden hindrance