Related Clues:

• Bother
• Concern
• Anxiety
• Distress
• See 7-Down
• Stew
• Trouble
• Fret
• Dog or hound
• Cause of wrinkles
• 'What, me ___?'
• Lose sleep over
• It "often gives a small thing a big shadow": old proverb
• ''What, me ___?''
• "What, me ___?"