Related Clues:

• Grandson of 5-Down
• Apple picker
• Role in Haydn's 'The Creation'
• See 51-Across
• Nephew of Cain
• Second person
• Birthright seller, in Genesis
• Offerer of lambs to God
• Start of something big
• Isaac's eldest
• Noted twin
• Night of celebration
• Big name in computer games
• Woman in a garden
• Threshold