Related Clues:

• Pester persistently
• Some athletes play through it
• Clubber Lang's prediction for Rocky
• Big inconvenience
• "Royal" nuisance
• T-___ (noted Auto-Tune user)
• "No __, no gain"
• "Royal" annoyance
• There's no gain without it
• Give grief to
• What lines with stars at the end indicate in comics
• Royal annoyance
• ___ in the neck
• "No ___, no gain" (gym saying)
• A pain in the brain