Related Clues:
- The principal pain?
- It comes with the gain game!
- Worry, trouble (colloq.)
- 'I'm very brave generally ... only today I happen to have a -' (Lewis Carroll)
- It is often gained
- Mental distress
- Ambassador confronts female rebel - nasty problem
- Suffering, distress
- It often comes with sporting gain
- Trouble ship had in sound
- Pester (colloq.)
- A bit of glass in one's ear can cause discomfort
- Harass, pester
- A sign of strain between opposing temples
- Having to pull round ship is a nuisance