Related Clues:

• Whips into a frenzy, with "up"
• Bugs a lot
• Infuriates
• Bugs to no end
• Needles or nettles
• Pisses off
• Inflames
• Really gets to
• Gets upset
• Angers, with 'up'
• Makes furious
• Annoys in American way
• Irritates, nettles
• Annoys, irritates
• Works (up)