Related Clues:

• Fuss and bother
• 10 Across or 49 Across
• Flea, e.g.
• Sitter's challenge
• Pain in the butt
• Mole, e.g.
• Annoying type
• Gadfly
• Annoying one
• Little brother, maybe
• Yapping dog, e.g.
• D-Con target
• Bug bomb target
• Buttinsky, e.g.
• Spammer, for one