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Related Clues:
- Gnat, for one
- Kid brother, stereotypically
- Major inconvenience
- Unwelcome greenhouse guest
- Pester persistently
- Big inconvenience
- Bugging bug
- With 65-Across, extermination ... or what can be done to 10 answers in this puzzle without affecting their clues?
- Cockroach or termite
- Vexatious one
- Irksome type
- Mosquito or fly
- Gnat, often
- Bug you want to swat
- Source of exasperation