Related Clues:

• Great pain
• Excruciation
• Anguish
• A long, amateurish piano recital, maybe
• Woe
• Cause for contortions
• Ecstasy's opposite
• ''. . . the ___ of defeat''
• Opposite of ecstasy
• Hell
• Major pain
• Emotion in defeat, sometimes
• Intense feeling
• It's a big pain
• "Into the Woods" song