Related Clues:

• Makes angry, with "up"
• Worries no end
• Invokes the anger of
• Makes hopping mad
• Bothers to no end
• Really troubles
• Bugs big-time
• Ruffles the feathers of
• Gets one's 53-Down
• Irritates incessantly
• Worries to no end
• Puts out of sorts
• Tries the patience of
• Is galling to
• Is bothersome to