Related Clues:

• It comes with painful defeat
• Distress, in a state after move
• Extreme suffering since New York's gone under
• Very great suffering
• Extreme anxiety
• Board game occupied some sort of aunt
• Past state brought woe
• Stone showed such pain associated with E
• Attire having to accommodate one stone extra brings grief
• Key is with lock: that spells trouble!
• Ecstasy's antithesis
• Go in some anguish
• First in line, which does make you unhappy
• I would return to emphasise the suffering
• Give medical assistance to first, amid the misery