Related Clues:

• Hell
• Major pain
• Emotion in defeat, sometimes
• Trouble for 12 Down
• Intense feeling
• It's a big pain
• "Into the Woods" song
• 'The ___ and the Ecstasy'
• Intense pain
• "... the __ of defeat"
• Ecstasy opposite
• Unending pain
• True pain
• Serious suffering
• High anxiety