Related Clues:

• What Des might see to do, being not at all happy
• Con used this to escape from his sisters there
• Mimi might well have done this, but not originally
• Formerly hearty enough to make one breathless
• By the sound of it, threw this out
• What big girls don't do, in a '60s hit
• Overreact to spilt milk
• Meditation instruction
• Blow off
• Finish respiring
• React, as most children to 29-Down's meme
• Act like a baby?
• Get out of breath, being no longer fit
• Expire, though previously fit as a fiddle
• An opening for five, possibly ten