Related Clues:

• Holiday
• With 100 Across, Interstate stop
• Vacation purpose, perhaps
• Indication to stop playing
• 'Later, dude!'
• ''The ___ is history''
• Informal farewell
• 'Bye'
• Staff marking
• Type of home or room
• Some medical advice
• Doctor's prescription, sometimes
• Sit for a spell
• Take a few minutes
• Take a time-out