Related Clues:

• Make unhappy
• Drove up the wall
• Like many a letter to the editor
• Hangdog
• Truman's defeat of Dewey, e.g.
• Paying for exercise?
• Pensive, perhaps
• Word with throat or loser
• A crying shame
• Really ruffle
• Low-spirited
• Really displeased
• Thumb or throat condition, perhaps
• Smarting
• Wistful