Related Clues:

• Sock mishap
• Monkey wrench
• Sweater woe
• It often leads to a run
• Plan impediment
• Trip up
• Fishing-line problem
• Hidden hindrance
• Become entangled
• Unforeseen glitch
• Hangup
• It might produce a run
• Pulled thread
• Glitch or hitch
• Reason to say 'Now what do we do?'