Related Clues:

• Major annoyance
• Extreme pain
• Great distress
• Big pain
• Great pain
• Fuss and bother
• Excruciation
• Anguish
• A long, amateurish piano recital, maybe
• Pain in the butt
• Woe
• Cause for contortions
• Ecstasy's opposite
• ''. . . the ___ of defeat''
• Opposite of ecstasy