Related Clues:

• Mostly run up and down
• Teary, maybe
• “Down” different initially, while going up
• "That's unfortunate!"
• "Alas, how tragic"
• Unhappy 16-Across
• In a crying mood
• Happy? No, not right
• Texting :-(, perhaps
• A long way from happy
• Broken up over a breakup, say
• Inapt rhyme of "glad"
• "It is ___ to grow old but nice to ripen" (Brigitte Bardot)
• In need of a hug, maybe
• "Makes me want to cry"