Related Clues:

• Grate on
• Get one's dander up
• Annoy greatly
• It must be managed
• Anger, with 'up'
• Evoke bitterness
• Antagonize
• Cause to see red
• Subject of a management course?
• Bug big-time
• Needle, perhaps
• Sorehead's emotion
• It may need some management
• Boil one's blood
• One might take classes to manage it