Related Clues:

• Blow it
• Fumble
• Muff
• Mishandle an opportunity
• Make an error
• Fail to get a job done
• Fail to follow through like a major leaguer
• Mishandle a situation
• Mess up ... and a hint to 17-, 24-, 36- and 50-Across
• *Make a mistake ... and what the answers to the starred clues do, in two ways?