Related Clues:

• Trial or tribulation
• Intro to zoology?
• Reason for hand-wringing
• Alas!
• Pitiful state: Ohio in Madonna film
• Misery, wretchedness
• Cause of dejection
• We hear call to stop misery
• Tales of __: misfortunes
• Major heartbreak
• Grief, misery
• 'Alas!' sentiment
• Blue period?
• Dolorous state
• Sad, sad situation