Related Clues:

• More than a little off
• Mad as can be
• Making no sense
• Obviously hot on the range
• In a frenzy: Var.
• One way to have gone
• Run ___ (go crazy)
• More than simmering
• Frothing
• One way to run?
• Run __ (rage)
• Wacky as can be
• Plumb __
• Run -- (go wild)
• Meshuga