Related Clues:

• Aggravation, so to speak
• Poetic grief
• Woe
• Heartbreak
• Word in a Charlie Brown phrase
• Painful grief
• Painful grief, in poetry
• Hassle, slangily
• Heavy heart
• Hard time, informally
• Annoyance, so to speak
• Feeling of loss
• Deep sorrow
• Deep sadness
• Reaction to personal loss