Related Clues:

• Dennis the Menace, to Mr. Wilson
• Mosquito or mole, e.g.
• Fly, perhaps
• 17-Across in the neck
• Annoying bug
• Irksome one
• Pain in the ass
• Tricky puzzle
• Bozo, in Bath
• Little puzzle
• One who 26-Across
• Destructive insect or nuisance
• A nuisance - step on it
• Troublesome man or animal
• Slangily a foolish person