Related Clues:

• Start of a grid-based game
• Opening in "Hollywood Squares," essentially
• Twinge, as of hunger
• "___-Tac-Dough" (quiz show)
• First X, potentially
• ___ Tac (breath freshener)
• "Twitch," minus every other letter
• Nervous twinge
• First O, maybe
• Guilt symptom
• Bit of guilt, say
• Opening in "Hollywood Squares"
• Sudden distress
• Involuntary muscle movement
• Feeling of desire