Related Clues:

• 10 Across or 49 Across
• Flea, e.g.
• Sitter's challenge
• Pain in the butt
• Biblical jawbone source
• Ignoramus
• Mole, e.g.
• Annoying type
• Smart ___ (wise guy)
• Gadfly
• Annoying one
• Little brother, maybe
• Obnoxious one
• Yapping dog, e.g.
• Laughingstock