Related Clues:

• Rile up
• Rile
• Stick in one's craw
• Grate on
• Annoy greatly
• Bug big-time
• Needle, perhaps
• Really annoy
• What nudniks do
• Chafe
• Bother the heck out of
• Gnaw at
• Really ruffle
• Annoy constantly
• Be a pest to