Related Clues:
- Ecstasy opposite
- One reason for taking aspirin
- Unending pain
- True pain
- Annoying situation
- Extreme suffering
- Serious suffering
- Major inconvenience
- ''. . . and the __ of defeat''
- Awful struggle
- Excruciating pain
- ". . . the ___ of defeat"
- 'There is no greater ___ than bearing an untold story inside you': Maya Angelou
- Song from Sondheim's 'Into the Woods'
- Great suffering