Related Clues:

• It can cause one to turn blue
• Unhappy state
• With 37-Down, popular book on grammar
• The 'vey' in 'oy vey'
• Ill
• Expression of grief
• Annoyance, so to speak
• Inner turmoil
• Sad state
• Source of despondency
• Wednesday's Child is full of it
• Feeling of regret
• It's hard to bear
• Cause for weeping
• Bad tidings