Related Clues:

• Disagreeable one
• Dose unit
• Vitamin unit
• Destructive insect
• Vexatious sort
• Irksome sort
• Medicine dose, perhaps
• Troublesome insect
• Obnoxious person
• 10 Across or 49 Across
• Flea, e.g.
• Sitter's challenge
• Rx unit
• Pain in the butt
• Mole, e.g.