Related Clues:

• Great distress
• Blue state?
• Anguish
• Doomsayer's cry
• Ills
• Tsuris, so to speak
• Unhappiness
• Cry for attention
• Heartbreak
• Adversity
• "Alas!"
• 'Alas ...'
• Begone beginning
• Unfortunate condition
• The 'vey' of 'oy vey!'