Related Clues:

• Got under one's skin
• Improbable win
• Nettled
• Really bugged
• Make unhappy
• Drove up the wall
• Truman's defeat of Dewey, e.g.
• Really ruffle
• Favorite's defeat
• Surprising game result
• Underdog's win
• In a state
• Not happy
• In need of antacid
• Underdog's victory