Related Clues:

• Employee's angry cry
• Sighed line
• Flip response?
• Comment after a difficult decision
• ''Alas!''
• "Uncle!" (essentially)
• Melodramatic cry
• Fed-up person's cry
• Words of wistfulness
• 'Life is hard ...'
• Sighed aside
• 'C'est la vie'
• 'How can ___?'
• 'Uncle!'
• Utterance that sums up 20-, 32- and 42-Across