Related Clues:

• Analgesic's target
• Ibuprofen target
• French bread
• Bodily distress
• Endorphins producer
• Woe
• Hassle
• Cause of a wince
• Harm
• Physical discomfort
• Major nuisance
• Player's sideliner
• Feeling that makes you say 'Ow!'
• Pulled hamstring, e.g.
• __ in the neck (pest)