Related Clues:

• Severe problem
• Vexing situation
• Pain in the neck to crown a revolutionary
• Source of concern
• Hangover symptom
• Pest on top of everything else is painful
• Imaginary source of fear
• Migraine, e.g
• Tailless monkey grabs rug right away - it's awful!
• The principal pain?
• Worry, trouble (colloq.)
• 'I'm very brave generally ... only today I happen to have a -' (Lewis Carroll)
• Ambassador confronts female rebel - nasty problem
• Bogey has to annoy: a shocking word
• A sign of strain between opposing temples