Related Clues:

• Really tick off
• Lire (anag)
• Get on someone's back
• Stir up, as sediment
• Honk off
• Rub up the wrong way with loud music to go off
• Make really mad
• Make murky
• Ruffle the feathers of
• Bug, and then some
• Irritate considerably
• Anger (with "up")
• Incite anger
• Stir up, as silt
• Ladder, part 6