Related Clues:

• Wear on one's conscience
• Bother big-time
• ___ Joe's
• "___ Joe's" (sandwich board message)
• Unmitigated ___
• Continuously bother
• Patronize, in a way
• Make anxious
• Really rankle
• Words on a sandwich board
• Brass nedk or bile
• Spleen or brass neck
• Bitterness of feeling or bodily bladder
• A sore spot or a bodily bladder
• This bladder is attached to the liver and stores bile