Related Clues:

• Impudence — annoy
• Impudence; bitterness
• Irk big-time
• "Unmitigated" nerve
• Irritate to no end
• Annoy to no end
• Sandwich board phrase
• 'The unmitigated ___!'
• Everlast album "___ Whitey's"
• 'Unmitigated' nerve
• Patronize, as a beanery
• Seriously worry
• Bother much
• Constantly bother
• Concern greatly