Related Clues:

• Little brother, maybe
• Yapping dog, e.g.
• D-Con target
• Bug bomb target
• Babysitter's nightmare
• Little brat
• Buttinsky, e.g.
• Spammer, for one
• Holy terror
• Mosquito, e.g.
• Unwelcome visitor
• Exterminator's quarry
• Constant interrupter
• Little annoyance
• Persistent annoyer