Related Clues:

• Do not start to pine despite great pain
• Island in area of Scotland beginning to harbour suffering
• Tight, forgetting source of latest unhappiness
• Pitiful state: Ohio in Madonna film
• Not generally the emotion of a blue movie?
• Regret impertinent talk about heads of department needing education
• The misery of winter?
• Some rockets send astronauts the wrong way, creating misery
• Fail to win compassion, become despondent
• Three also involved become disillusioned
• Using shot in a hospital for extreme pain
• Stands regularly on head, causing pain
• Wilt, when lead's lost, causing anxiety
• Students initially notice head's misery
• Intense unhappiness