Related Clues:

• Major setback
• Sudden bit of bad news
• Off, in mobspeak
• Lam it
• Squander, as a wad of cash
• Really ruin
• With 'job,' what a 46-Across might do
• Command to Gabriel
• Diddle away
• Low __: cheap shot
• Be windy; unlucky stroke
• Strike; share (slang)
• A low one is illegal
• One to the body, perhaps
• Sudden shock, wind