Related Clues:

• It must be managed
• Anger, with 'up'
• Antagonize
• Cause to see red
• Subject of a management course?
• Sorehead's emotion
• It may need some management
• Boil one's blood
• One might take classes to manage it
• Really annoy
• Red state?
• Bring exasperation
• Chafe
• Make hot
• Get hot