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Related Clues:
- Aches and pains
- Thorns in one's side
- Archenemies
- Problems, problems
- Causes of distress
- They're no good
- Blights
- Reform targets
- They're all bad
- Poverty, pollution and such
- Woes, as of the world
- Contents of Pandora's box, except for hope
- Societal problems
- Subject of therapy
- Escapees from a mythical box